Thus, our study contributes to the better understanding of the mechanism of mycobacterial biofilm formation and sheds light on the role of LuxS product homocysteine. ![]() Exogenous supplementation of homocysteine in the culture media leads to aberrant cording, pellicle outgrowth, and biofilm formation. We here show the effect of LuxS product-homocysteine, on the biofilm forming ability of non-tuberculous mycobacteria, Mycobacterium smegmatis and Mycobacterium bovis BCG showing AI-2 independent phenotypic effect of LuxS. LuxS has been previously known to play a role in biofilm formation in Autoinducer-2 dependent manner. Despite years of research, very little is known about the mechanisms that contribute to biofilm formation. Biofilms harbor antibiotic resistant bacteria in a self-produced extracellular matrix that signifies the bacterial fate to sedentary existence. Mycobacteria show peculiar aggregated outgrowth like biofilm on the surface of solid or liquid media.
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